Plasma von Willebrand Factor in Patients with Megaloblastic Anemia
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چکیده
منابع مشابه
Plasma von Willebrand factor abnormalities in patients with essential thrombocythemia.
Plasma von Willebrand factor (vWF) in eleven patients with essential thrombocythemia was studied quantitatively and qualitatively to assess its role in the development of bleeding tendency. Five patients with prolonged bleed ing time including three with clinical bleeding tendencies showed decreased ristocetin cofactor (VIIIR: RCo) and factor VIII-related antigen (VIIIR: Ag). On the other hand,...
متن کاملRegulation of plasma von Willebrand factor
Von Willebrand factor (VWF) is a multimeric plasma glycoprotein that plays a central role in the initiation of blood coagulation. Through interactions between its specific functional domains, the vascular wall, coagulation factor VIII, and platelet receptors, VWF maintains hemostasis by binding to platelets and delivering factor VIII to the sites of vascular injury. In the healthy human populat...
متن کاملMegaloblastic Anemia in Pregnancy
MegalobJastic Anemia in Pregnancy Megaloblastic Anemia is one of The Rather Common Diseases of Pregnant Women Caused by Folic acid Deficiency The Disease Might Be Hazardous To affected Mothers and also Could be Fatal for foetus too. Megaloblastic Pregnant Women Will have Signs and Symptoms of This Disease mostly after 29th. Week of pregnancy. Adequate amount of Folate Will prevent Compli...
متن کاملAbnormal VIII: von Willebrand factor patterns in the plasma of patients with the hemolytic-uremic syndrome.
Plasma VIII:von Willebrand factor antigen (VIII:vWF) levels were elevated approximately two- to eightfold in seven patients (three adults and four children) during acute episodes of thrombocytopenia, renal failure, and hemolytic anemia (the hemolytic-uremic syndrome, HUS). In all seven patients, there was an alteration in plasma VIII:vWF patterns during these acute HUS episodes, so that the lar...
متن کاملSubunit composition of plasma von Willebrand factor in patients with the myeloproliferative syndrome.
In order to evaluate the role of proteolysis in acquired von Willebrand's disease (vWD) associated with the myeloproliferative syndrome, we have determined the relative quantity of von Willebrand factor (vWF) fragments as compared with the intact 225 kDa subunit in four patients. The plasma vWF of each individual lacked large multimers; each had a prolonged bleeding time; and both platelet and ...
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ژورنال
عنوان ژورنال: Japanese Journal of Thrombosis and Hemostasis
سال: 1991
ISSN: 1880-8808,0915-7441
DOI: 10.2491/jjsth.2.122